Bioactive Small Molecules
Medchemexpress LLC Bezisterim | 1001100-69-1 | 95.0% | 330.46 g·mol⁻¹ | C21H30O3 | 5 MG
Bezisterim is an orally active, small-molecule partial NF-κB inhibitor and a synthetic derivative of the endogenous anti-inflammatory steroid β-AET. It is used in preclinical research to study inflammation-related signaling and disease models where modulation of NF-κB activity is relevant.
- Partial NF-κB inhibition useful for inflammation pathway studies.
- Orally active chemical profile suitable for in vivo experiments.
- Molecular formula C21H30O3; molecular weight 330.46 g·mol⁻¹.
- CAS number 1001100-69-1 for unambiguous identification.
- Purity reported as 95.0% for research-grade applications.
- Offered in small solid pack sizes for dosing and formulation flexibility.
Medchemexpress LLC N,S-Bis-Fmoc-Glutathione (TFA) | 149438-56-2 | 751.8 | 50 MG
N,S-Bis-Fmoc-glutathione is a sophisticated glutathione derivative for advanced applications in peptide synthesis and drug development. Its unique structure enhances stability and solubility, suitable for researchers in bioconjugation and targeted therapies. Protective Fmoc groups enable selective deprotection, facilitating precise synthesis. This product is for research use only, intended for laboratory chemicals and substance manufacturing.
- Acts as a protecting group in peptide synthesis, allowing selective modification of amino acids.
- Crucial for developing new pharmaceuticals, targeting specific biological pathways.
- Used to attach biomolecules to surfaces, enhancing drug delivery and diagnostic tools.
- Enables the study of oxidative stress mechanisms and development of therapeutic strategies.
- Employed in analytical techniques to improve assay sensitivity and selectivity in biochemical research.
Cayman Chemical ANTIBODY U-74389G 100mg
U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against is chemia-reperfusion injury in animal heart, liver, and kidney models.{4561,4612,4562,4567}
Medchemexpress LLC 3-Fluoro-4-methoxybenzaldehyde | 351-54-2 | 154.14 | 5 G
3-Fluoro-4-methoxybenzaldehyde (3-Fluoro-para-anisaldehyde) is a drug intermediate used in the synthesis of fluorinated derivatives of Combretastatin A-4, which possesses anti-cancer activity. It is for research use only.
- Can be used to synthesize fluorinated derivative of Combretastatin A-4
- Possesses anti-cancer activity
- For research use only
- Molecular weight: 154.14
- Formula: C8H7FO2
- Appearance: Liquid
- Color: Light yellow to yellow
Medchemexpress LLC N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys | 71901-21-8 | 98.9% | 824.02 | 50 MG
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist. It is suitable for laboratory research, appearing as a solid with a white to off-white color. The product is for research use only.
- Formyl peptide receptor (FPR) agonist
- Appearance: Solid, white to off-white
- Sequence: N-Formyl-{NLE}-Leu-Phe-{NLE}-Tyr-Lys
- Recommended storage for powder: -80°C for 2 years or -20°C for 1 year
- Recommended storage in solvent: -80°C for 6 months or -20°C for 1 month (sealed, away from moisture)
Cayman Chemical 11-Hydroxyprogesteron 5mg
A metabolite of progesterone; an MR agonist (EC50 = 0.05 µM in a reporter assay); an inhibitor of 11β-HSD2 and 11β-HSD1 (IC50s = 0.140 and 1 µM, respectively); increases blood pressure in rats at 10 UG/hour; serum levels are increased in patients with 21-hydroxylase deficiency
Cayman Chemical ANTIBODY ERB 041 5mg
An ERβ agonist (IC50s = 5.4, 3.1, and 3.7 nM for the human, rat, and mouse receptors, respectively); selective for ERβ over ERα (IC50s = 1,200, 620, and 750 nM for the human, rat, and mouse ERα, respectively); induces IGFBP4 mRNA expression in Saos-2 cells expressing human ERβ (EC50 = 20 nM); inhibits chronic diarrhea and reduces colonic ulceration, inflammation, and fibrosis in the HLA-B27 transgenic rat model of inflammatory bowel disease at 0.1 and 0.3 mg/kg; reduces joint swelling in a rat model of adjuvant-induced arthritis at 1 mg/kg; reduces lesion formation in a mouse model of endometriosis at 10 mg/kg
Medchemexpress LLC Lagipra peptide TFA | 98.2% | 5756.50 | 25 MG
LAGIPRA peptide TFA is a long-acting GIP1R agonist. It enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. It has potential for the research of type 2 diabetes.
- Long-acting GIP1R agonist
- Enhances insulin sensitivity
- Augments glucose disposal
- Reduces branched-chain amino acids (BCAAs)
- Reduces ketoacids
- Potential for type 2 diabetes research
Cayman Chemical ANTIBODY NIBR0213 10mg
A potent and selective S1P1 antagonist (IC50s = 2.5 and 2.0 nM for hS1P1 Ca2+ mobilization and in a GTPγS assay); inactive at S1P2, S1P3, and S1P4 receptors (IC50s = >20, >10, and >10 µM, respectively in a Ca2+ mobilization assay); reduces EAE disease severity in mice up to 26 days; induces pulmonary damage in rats when administered chronically
Medchemexpress LLC Caloxin 1C2 | 99.5% | 1844.08 | 25 MG
Caloxin 1C2 is a specific plasma-membrane Ca2+-ATPases (PMCA) inhibitor. It exhibits selectivity for PMCA4 over PMCA1, 2, and 3, and does not significantly affect total Ca2+ transfer. This inhibitor also impacts coronary contractility.
- Specific PMCA inhibitor
- Selective for PMCA4 over PMCA1, 2, and 3
- Does not significantly affect total Ca2+ transfer
- Affects coronary contractility
- Ki for PMCA4 is 2.3 ± 0.3 μM
- Ki for PMCA1 is 21 ± 6 μM
Cayman Chemical ANTIBODY IPG-2 AM 500ug
A cell-permeable fluorescent potassium indicator; binds to potassium (Kd = 18 mM); ex/em = 525/545 nm, respectively; has been used to kinetically monitor potassium levels in isolated human platelets via flow cytometry
Cayman Chemical TalaporfInsodIum salt 5mg
A photosensitizer; induces apoptosis, DNA DSBs, and the production of ROS in TE-11R 5-fluorouracil-resistant cells at 30 UG/ml in combination with radiation; reduces tumor growth in a TE-11R ESCC mouse xenograft model at 2.5, 5, and 10 mg/kg in combination with PDT
Selleck Chemical LLC LY3009120
LY03009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM 31-47 nM and 42 nM for A-raf B-Raf and C-Raf in A375 cells respectively LY03009120 induces autophagy Phase 1
Selleck Chemical LLC Uzansertib S8800-5MG
Uzansertib (INCB053914) is a novel ATP-competitive small molecule pan-inhibitor of PIM kinases with IC50 values of 0 24 nM 30 nM and 0 12 nM for PIM1 PIM2 and PIM3 respectively in biochemical assays